Total organic carbon (VCSN and VWP) and HPLC analysis for cleaning validation in a pharmaceutical pilot plant
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/19455941
其他信息:
PMID: 19455941
作者: M Queralt; E García-Montoya; P Pérez-Lozano; J M Suñé-Negre; M Miñarro; ...
摘要: This paper presents a useful method using total organic carbon analyzers employing both combustion and wet oxidation for validating equipment cleaning procedures and verifying cleaning in a pharmaceutical pilot plant. The results are compared with those obtained using high-performance liquid chromatography. The study summarizes the initial steps that should be taken into account and focuses particularly on the solutions to some of the most critical considerations (e.g., glass material, detection...
