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Conjugation site influences antibody-conjugated drug PK assays: case studies for disulfide-linked, self-immolating next-generation antibody drug conjugates复制

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MV Lee, S Kaur, OM Saad
Analytical chemistry, 2020
ACS Publications
Immunoaffinity (IA) LC-MS/MS pharmacokinetic (PK) assays are widely used in the field for antibody drug conjugates (ADCs) containing peptide linkers that are enzymatically cleavable, such as MC-ValCit-PAB. Conjugate PK assay strategies for these ADCs involve cleavage with cathepsin B or papain to release and measure the antibody-conjugated drug (acDrug) concentration. However, robust acDrug PK methods for disulfide-linked self-immolating ADCs are lacking as they are a different conjugation modality. We developed …

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