Identification of Potential Targets for Atherosclerosis and Functional Validation in ox-LDL-Induced Injury of Human Umbilical Vein Endothelial Cells
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LX Yan, K Yan, Y Wang, L Wu, PF He…
Journal of Applied …, 2026
Wiley Online Library
This study aims to screen potential regulatory targets for atherosclerosis (AS) through bioinformatics and explore the mechanism of these targets in ox-LDL-induced injury in HUVECs, thereby providing novel therapeutic targets for AS. The GEO dataset GSE43292 was obtained. Differentially expressed genes were screened using the limma package. AS-related genes were identified via LASSO regression and SVM algorithms. ssGSEA was performed to detect relative immune cell expression, followed by correlation analysis …
