Pharmacokinetics of orally administered estradiol valerate. Results of a single-dose cross-over bioequivalence study in postmenopausal women
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/9793623
其他信息:
PMID: 9793623
作者: H Zimmermann; R Koytchev; O Mayer; A Börner; U Mellinger; ...
摘要: A randomized, single-dose cross-over study in 32 postmenopausal women was performed to demonstrate bioequivalence of two estradiol valerate containing formulations (first sequence of Klimonorm as test preparation). The serum levels of estradiol, free and conjugated estrone were measured until 48 h after an oral dosage of 4 mg estradiol valerate (CAS 979-32-8). The mean AUC(0-48) of estradiol was calculated as 1006.6 /- 479.4 h x pg x ml-1 (Test) and 1015.2 /- 555.2 h x pg x ml-1 (Reference). T...
