Bispecific antibodies
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RE Kontermann, U Brinkmann
Drug discovery today, 2015
Elsevier
Bispecific antibodies (bsAbs) combine specificities of two antibodies and simultaneously address different antigens or epitopes. BsAbs with 'two-target'functionality can interfere with multiple surface receptors or ligands associated, for example with cancer, proliferation or inflammatory processes. BsAbs can also place targets into close proximity, either to support protein complex formation on one cell, or to trigger contacts between cells. Examples of 'forced-connection'functionalities are bsAbs that support protein complexation in the clotting …
