异烟肼是人肝微粒体中细胞色素P450 1A2、2A6、2C19和3A4同工酶的机制性抑制剂。
DOI:
文献链接: https://link.springer.com/article/10.1007/s00228-001-0396-3
其他信息:
X Wen、JS Wang、PJ Neuvonen…
欧洲临床杂志…，2002 年
Springer
Objective: In order to evaluate the inhibitory effects of isoniazid on cytochrome P 450 (CYP) mediated drug metabolism, the in vitro inhibitory potency and specificity as well as the reduced nicotinamide adenine dinucleotide phosphate (NADPH)-, time-and concentration dependency of isoniazid as an inhibitor of the activity of the major human CYP isoforms were studied. Methods: Using pooled human liver microsomes, the in vitro inhibitory effects of isoniazid on CYP1A2 (phenacetin O-deethylation), CYP2A6 (coumarin 7-hydroxylation) …
