Site‐Selective C–H/C–H Cross Dehydrogenative Coupling Between Quinoxalin‐2 (1H)‐Ones and Aliphatic Nitriles
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Y Xue, Y Zhang, C Li, Z Fang…
European Journal of …, 2026
Wiley Online Library
An efficient and facile method was developed for the synthesis of C3‐cyanoalkylated quinoxalin‐2 (1H)‐ones via a C–H/C–H cross dehydrogenation coupling between quinoxalin‐2 (1H)‐ones and aliphatic nitriles. The method enables the β‐or γ‐site‐selective C− H activation of aliphatic nitriles, giving the corresponding products in moderated to good yields. The reaction demonstrated a broad substrate scope and useful synthetic application ability.
