Mechanistic insights into RNA cleavage by human Argonaute2–siRNA complex
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Z Li, Q Xu, Y Zhang, J Zhong, T Zhang, J Xue, S Liu…
Cell Research, 2025
nature.com
In animals, AGO-clade Argonaute proteins utilize small interfering RNAs (siRNAs) as guides to recognize target with complete complementarity, resulting in target RNA cleavage that is a critical step for target silencing. These proteins feature a constricted nucleic acid-binding channel that limits base pairing between the guide and target beyond the seed region. How the AGO–siRNA complexes overcome this structural limitation and achieve efficient target cleavage remains unclear. We performed cryo-electron microscopy of human AGO–siRNA …
