Prediction of in vivo nonlinear first-pass hepatic metabolism of YM796 from in vitro metabolic data
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/9655850
其他信息:
PMID: 9655850
作者: T Iwatsubo; A Hisaka; H Suzuki; Y Sugiyama; T Iwatsubo; ...
摘要: Recent cumulative evidence suggests the possibility of predicting the in vivo metabolic clearance and/or hepatic availability (Fh) from in vitro metabolism data under linear conditions. Under nonlinear conditions, however, it is essential to consider the rate constant for the absorption (ka) for predicting Fh after oral administration, because the time profiles for the portal vein concentration depends on ka. In our study, we numerically solved the dispersion model under nonlinear conditions to ...
