Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle Cremophor EL
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/8616858
其他信息:
PMID: 8616858
作者: A Sparreboom; O van Tellingen; W J Nooijen; J H Beijnen; A Sparreboom; ...
摘要: Studies in humans and mice have demonstrated a nonlinear pharmacokinetic behavior of paclitaxel. Because of its poor water solubility, the drug is formulated in a mixture of Cremophor EL and ethanol (1:1, v/v; Taxol). We hypothesized that the substantial amounts of concurrently administered Cremophor EL on the disposition of paclitaxel, female FVB mice received paclitazel by i.v. injection at does levels of 2, 10, and 20 mg/kg by appropriate (standard) dilution of the commercially available form...
