期刊论文NTX-452: a non-covalent, potent, selective and highly efficacious WRN inhibitor with best-in-class potential for the treatment of MSI-H tumors复制

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R Svensson, S Boiko, B Browning, S Carreiro…
Cancer …, 2025
aacrjournals.org
Microsatellite instability (MSI-H) is a phenotypic consequence of defective mismatch repair (dMMR) in cancer and is observed in over 20 solid tumor types, with the highest prevalence in colorectal, gastric and endometrial cancers. While the treatment landscape of MSI-H is improving with the use of immune checkpoint inhibitors, substantial unmet medical need remains for patients with MSI-H cancers that fail to respond or relapse on standard-of-care therapies. Werner Syndrome Helicase (WRN) has been validated as a promising synthetic …