Four-week Repeated Dose Toxicity Study of Recombinant Human Basic Fibroblast Growth Factor by Subcutaneous Administration in Rats
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BO Ahn, DH Kim, H Cho, KK Kang, BS Park…
Toxicological …, 1999
dbpia.co.kr
Toxic effects of recombinant human basic fibroblast growth factor (bFGF) were investigated in Sprague-Dawley rats by repeated subcutaneous administration. Four groups of 10 male and 10 female rats were treated with bFGF at doses of 0 (control), 40, 200, or 1000㎍/kg/day for 4 weeks. Additional 5 male and 5 female rats were used in control and high dose group to evaluate the reversibility of any treatment-related adverse effects. During the study, all rats survived until the end of the study. Noteworthy signs of toxicity at 200㎍/kg and above were …
