Biotransformation of pravastatin sodium in humans
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/1680649
其他信息:
PMID: 1680649
作者: D W Everett; T J Chando; G C Didonato; S M Singhvi; H Y Pan; ...
摘要: Pravastatin sodium (PV) is a potent cholesterol-lowering agent that acts by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Biotransformation profiles of PV in pooled human urine, plasma, and feces from healthy male volunteers given single 19.2-mg oral or 9.9-mg iv doses of [14C]PV were determined by HPLC. The predominant drug-related component in urine, plasma, and feces corresponded to intact PV; in the pooled urine samples, PV constituted 29 and 69% of the radioactivity after the ...
