Site-specific O-glycosylation analysis of therapeutic Fc-fusion protein by mass spectrometry
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DOI:
文献链接: https://doi.org/10.1248/yakushi.18-00020-2
其他信息:
N Hashii, A Ishii-Watabe
… : Journal of the Pharmaceutical Society of …, 2018
europepmc.org
Therapeutic Fc-fusion proteins, created by linking bioactive peptides or receptor proteins to the Fc moiety of IgG, are currently being developed. In this development process, a Gly-Gly-Gly-Ser linker (G4S linker) is often used to link the peptide/protein and the Fc portion. O-xylose-type core glycans of glycosaminoglycan are known to attach to the Ser residue on the GSG motif in the G4S linker peptide repeats of the Fc fusion protein produced using the Chinese hamster ovary (CHO) cell expression system. In addition, a recent report …
