Pharmacokinetics of clarithromycin citrate salt after oral administration to beagle dogs and food effects on its absorption
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XR Zhang, YF Zhang, J Wang, HB Zhou…
PDA Journal of …, 2008
journal.pda.org
To investigate the pharmacokinetics of clarithromycin citrate salt and the effect of food on the absorption of free base and citrate salt, clarithromycin citrate was prepared and the in vitro intrinsic dissolution profiles of the free base and the salt were examined at pH 5.0 and pH 6.8. The pharmacokinetic profiles of clarithromycin following a single oral administration as the free base and its citrate salt (equivalent to 75 mg clarithromycin) were evaluated in eight beagle dogs. The plasma concentrations of clarithromycin were determined by reversed …
