Mutant Forms of Nucleoside Phosphorylases and Other Nucleic Acid Metabolism Enzymes for the Optimization of Cascade Synthesis of Modified Nucleosides
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EA Zayats, YA Abramchik, MA Kostromina…
Russian Journal of …, 2026
Springer
Modified nucleoside drugs are used in clinical practice to treat oncohematological diseases (nelarabine, fludarabine, cladribine, clofarabine) and viral infections (vidarabine, ribavirin, etc.) in the human body. The development of efficient technologies for the production of pharmaceutical substances is an important task for medical biotechnology. There are two main approaches to the synthesis of modified nucleosides: chemical and enzymatic. Traditional chemical synthesis technologies are often complex, labor-intensive, and …
