FL118, a novel camptothecin analogue, overcomes irinotecan and topotecan resistance in human tumor xenograft models
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/26692923
其他信息:
PMID: 26692923
作者: Xiang Ling; Xiaojun Liu; Kai Zhong; Nicholas Smith; Joshua Prey; ...
摘要: Irinotecan and topotecan are the only camptothecin analogues approved by the FDA for cancer treatment. However, inherent and/or acquired irinotecan and topotecan resistance is a challenging issue in clinical practice. In this report, we showed that FL118, a novel camptothecin analogue, effectively obliterated human xenograft tumors that acquire irinotecan and topotecan resistance. Consistent with this finding, Pharmacokinetics studies indicated that FL118 rapidly clears from circulation, while e...
