Solubilization of aluminum-containing adjuvants by constituents of interstitial fluid
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SJ Seeber, JL White, SL Hem
PDA Journal of Pharmaceutical …, 1991
journal.pda.org
The solubilization of three commercially available aluminum-containing adjuvants by citrate anion was studied. Amorphous aluminum hydroxy phosphate and boehmite were both solubilized, however, amorphous aluminum hydroxyphosphate dissolved significantly faster than boehmite. The results suggest that citrate and other α-hydroxy carboxylate anions in the interstitial fluid are able to solubilize and thereby facilitate the excretion of aluminum from aluminum-containing adjuvants which are administered by intramuscular injection. The …
